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Any accumulation of AGE is associated with various diseases, such as diabetes mellitus type 2, metabolic syndrome, cardiovascular diseases, ovarian aging, neurodegenerative disorders, obesity and PCOS [33, 34, 35]

Hassellund et al., 2013

A major limitation of the present study is the cross-sectional design of the analyses, which estimated the associations between AC levels and depression at the same assessment (either baseline or 6-year follow-up), precluding conclusions about causality