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Mitochondria-derived reactive oxygen species mediate caspase- dependent and-independent neuronal death

Another form of renal toxicity, generally associated with NSAIDs, is seen in patients with prerenal conditions leading to the reduction in renal blood flow or blood volume, where the renal prostaglandins have a supportive role in maintaining renal perfusion

For example, in follicular lymphoma (FL) patients, recurrent loss-of-function mutations are identified in the ATP6V1B2 , VMA21 , and ATP6AP1 genes encoding a V-ATPase V 1 domain component and two assembly factors 10,11,12,13,14