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118,119 The pathogenesis of DR is complex, with emerging evidence highlighting the role of premature senescence in retinal cells and the secretion of inflammatory cytokines that exacerbate disease progression through paracrine senescence and pathological angiogenesis

Therefore, in addition to GSSG accumulation, a decrease in Grx expression/activity may also lead to increased protein S -glutathionylation

Sources: Hangovers - Symptoms and causes | The Mayo Clinic Drug Bioavailability - StatPearls | NCBI Bookshelf

These responses can promote the development of food-specific IgE and reshape the gut immune microenvironment in a manner that predisposes to IgE-mediated activation of mast cells and clinical manifestations of allergic disease following subsequent food exposures