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A: Die-off symptoms typically come on quickly after starting treatment and subside in a few days

Additionally, treatment with 10 nM E2, for 7 days, stimulated differentiation to the neuronal lineage, and inhibited differentiation to astrocytes (Zhang et al., 2019)

Molewaterplein 40, 3015 GD Rotterdam, The Netherlands Tel: +31-107032861, Fax: +31-107033639, E-mail: a.vanderlelij@erasmusmcnl Received: October 30, 2023 Revised: November 23, 2023 Accepted: December 6, 2023 Copyright 2024 Korean Endocrine Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited