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Accumulating experimental evidence points to oxidative stress as a pathogenic factor in RP

These results produce a physiological milieu in which immunomodulatory therapies, such as microglia-calming drugs, inflammasome inhibitors, and T-cell-regulating biologics, can be more effective and have less inflammatory resistance

Nonetheless, the present study does not directly identify the chemical modification, the modified residues/bonds, or the structural mechanism, all of which await further study

Nucleic Acids Res 38:72487259 Wang HJ, Deng J, Wang JY, Zhang PJ, Xin Z, Xiao K, Feng D, Jia YH, Liu YN, Xie LX (2014) Serum miR-122 levels are related to coagulation disorders in sepsis patients