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Funding This research was supported by grants for the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (Grant Number: 2019R1A2C2086729)

While hydroxocobalamin is not already methylated, it is readily converted to this form to support the methylation cycle

We observed that Collinsella had an opposite trend compared to that of Lactobacillus , and a previous study had described the same inverse relationship between these two genera [62], which might indicate a possible link between the abundance of these two groups

Pathophysiology of Thalassemia Thalassemia disrupts the bodys ability to produce functional hemoglobin, resulting in ineffective erythropoiesis and chronic anemia