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Moniruzzaman M, Ghosal I, Das D, Chakraborty SB (2018) Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk/Akt/ NFkB pathway

We have recently identified a set of 15 genes, called A nti-oxidant C apacity B iomarkers (ACB) which accurately predict the sensitivity of cell lines across various cancer types to redox-targeting drugs such as ferroptosis inducers (GPX4 inhibitors) or thioredoxin reductase 1 (TXNRD1) inhibitors 15

10.2174/1568026614666140929124445 Curr

To further validate this observation, we treated MTEC and 16HBE separately with cigarette smoke extract (CSE) and garlic oil, as well as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a compound also known as a key carcinogen in tobacco