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proposed that neutrophils may initiate compensatory FAO due to impaired glucose and glutamine metabolism as well as reduced lactate production and diminished PPP activity, which overall was associated with impaired phagocytosis and H 2 O 2 production ( 6 Metabolic alterations in endothelial cells in the context of inflammation and atherosclerosis ECs are the lining between the circulation and the vessel wall and thereby play a crucial role in the regulation of leukocyte recruitment

When the "safe" pathways in the liver become overwhelmed, more of the medication is pushed through the pathway that creates NAPQI

Hum Exp Toxicol 40 : S447S459