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10.1155/2021/3687700 66 ShemeshO

doi: 10.1074/jbc.M117.776021 81 YanatoriIRichardsonDRImadaKKishiF

Microbiome-directed probiotic interventions have shown promise in preclinical and clinical studies, ameliorating UC through multiple mechanisms, including anti-inflammatory activity, epithelial barrier restoration, and remodeling of the intestinal microbiota

Enhancing synaptic plasticity, stimulating intrinsic cytoprotective pathways, and delivering neurotrophic support are necessary, but insufficient steps