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When researchers use this compound in studies, it activates these receptors to affect multiple cellular pathways

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Similar to NNMT overexpression, MNA-treated hepatocytes show a dose-dependent increase in glucose production, Sirt1 protein expression, G6pc mRNA expression, and Pck1 mRNA expression compared to controls and these changes caused by MNA treatment can be abolished by Sirt1 knockdown [14]