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Additionally, individuals with a B12 deficiency may experience mood changes, such as depression or irritability, as B12 plays a role in the production of neurotransmitters that regulate mood

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

TB 500: 25 mg weekly, often used systemically

This emphasizes the potential importance of detecting high tHcy in middle aged women, as homocysteine lowering treatment, if shown promising in ongoing and future studies, is safe and not costly - Zylberstein et al, Neurobiological Aging, 2011 By the way, this study was in 2011, so where are the studies following up on this