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4.3.2 Adeno-associated virus Adeno-associated viruses (AAVs), which are composed of a protein shell that surrounds and protects a small, single-stranded DNA genome of approximately 4.8 kb, can deliver DNA to target cells (100)

In the future, it is essential to systematically assess the in vivo distribution and metabolic efficiency of nanozymes in animal models, explore safe dose ranges for different types of nanozymes, and consider the potential long-term toxicity risks of material degradation products

In osteoarthritis (OA), research has also demonstrated that IgE-mediated mast cells can be activated via FcRI and Syk, leading to mast cell degranulation and the release of pro-inflammatory factors and cartilage-degrading mediators (including tryptase), resulting in cartilage and joint destruction and aggravating OA cartilage damage (132)

In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors