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For systemic applications targeting pulmonary fibrosis, cognitive decline, or general anti-aging effects, the delivery problem becomes substantially harder

The intestinal microflora and the CNS are connected in two directions: through neuronal pathways, gastrointestinal metabolites, and immune signaling [60]

These are usually bound to proteins with characteristic acyl-CoA binding domains and depending upon on the energy status of the cell, they are directed to particular metabolic pathways such as storage or energy production by many different proteins including fatty acid binding proteins and sterol carrier protein 2