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Transient and mild stress (such as transient ischemic preconditioning) can induce moderate mitophagy to exert a protective effect, while sustained and high-intensity stress (such as long-term severe ischemia and severe oxidative stress) is prone to trigger excessive mitophagy, shifting the regulatory effect toward damage

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The rate of congenital malformations among babies born to mothers using valproate is about four times higher than the rate among babies born to epileptic mothers using other anti-seizure monotherapies

doi: 165