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Precautions for Use and Management

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In the field of allo-HSCT, a number of publications have shown an association between gene polymorphisms in the Cy metabolism pathway and post-transplantation complications ( Another important drug used in the conditioning regimen for HSCT is busulfan, which is an alkylating agent generally metabolized in the liver via conjugation with glutathione, which is catalyzed by GST enzymes, predominantly GSTA1, GSTM1 and GSTT1

February 17, 2026 Key Takeaways: Chemical sensitivity signals overwhelmed detox capacity, reflecting how glutathione deficiency limits your body's ability to get rid of toxins efficiently