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Haematologica 103 , 361372

As a major source of ROS, primarily superoxide, generated as byproducts of OXPHOS at Complexes I and III [3], mitochondria possess antioxidant systems including superoxide dismutase 2, glutathione peroxidase, and catalase to neutralize ROS

Subsequent investigations have demonstrated that histone Kla can directly enhance the transcription and expression of stable genes by modulating chromatin accessibility