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Enveloped nano-complexes with an amphiphilic polymer poly(glutamic acid)-PEG (PGA-PEG) to transport miRs to the brain and modulate its mRNA targets [127]

36,37 Regarding molecular mechanisms underlying macrophage polarization, we found both p-JNK and p-NF-B to be notably increased in LPS-stimulated RAW264.7 cells but decreased after the hUC-MSCs treatment, suggesting that hUC-MSCs suppress LPS-induced macrophage M1 polarization by inhibiting JNK and NF-B activation

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Accordingly, one aspect of the invention relates to diagnostic assays for determining NOVX protein and/or nucleic acid expression as well as NOVX activity, in the context of a biological sample (e.g., blood, serum, cells, tissue) to thereby determine whether an individual is afflicted with a disease or disorder, or is at risk of developing a disorder, associated with aberrant NOVX expression or activity