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For severe major depressive disorder [identified using a Patient Health Questionnaire (PHQ)-9 score 20], an integrated approach combining pharmacotherapy and psychotherapy is preferred

For example: Chronic mild stress inhibits mitochondrial function at respiratory chain complexes I, III, and IV.[ref] Lets dig into chronic stress further: Chronic stress: a cause of mitochondrial dysfunction

Under low-oxygen conditions, mitochondrial electron transport chain dysfunction and hypoxia-induced activation of oxidases [478] synergistically drive pathological ROS accumulation [479] that overwhelms cellular antioxidant defenses

Interpreting Ph results A pH reading below 7 indicates acidity, while above 7 signifies alkalinity