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These stem mainly from the very weak signals and significantly delayed inflection points caused by their extremely slow growth rates

Geldmacher von Mallinckrodt, Institut fr Rechtsmedizia, Erlangen, Germany Dr A

For non-hematological AEs using multivariate logistic regression analysis, the C/T genotype group of MTHFR_a , high serum RBP level before pemetrexed treatment, high serum B12 level before premedication, and high red blood cell (RBC) count before pemetrexed treatment (Supplementary Table S3(a)) were the crude low-risk factors for G2G4 non-hematological AEs in the first cycle

Third, although we performed statistical adjustments, the bias of these background factors could not necessarily be eliminated