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Glutathione peroxidase 3 (GPX3) suppresses the growth of melanoma cells through reactive oxygen species (ROS)-dependent stabilization of hypoxia-inducible factor 1- and 2-

doi: 10.1038/cdd.2014.218 275 KolahgarGSuijkerbuijkSJKucinskiIPoirierEZMansourSSimonsBDet al

The study shows that female patients with melanoma had significantly better responses to BRAFMEK-targeted therapy than male patients, and in preclinical melanoma models, elevated AR expression impaired treatment efficacy, while AR inhibition improved responses

Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region