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Abbreviations ABCA1 ATP binding cassette subfamily A member 1 ABCC4 ATP binding cassette subfamily c member 4 ADIPOQ Adiponectin AdipoR2 Adiponectin receptor 2 A-FABP Adipocyte fatty acid-binding protein AhR Aryl hydrocarbon receptor AIs Artificial intelligence applications AOX Aldehyde oxidase APOA5 Apolipoprotein A5 APRI AST to platelet ratio index AR Androgen receptor BMAL1 Basic helix-loop-helix ARNT like 1 BMI Body mass index BTG1 BTG anti-proliferation factor 1 CAR Constitutive androstane receptor CDAA Choline-deficient L-amino-acid-defined diet CDK Cyclin-dependent kinase CDKL2 Cyclin-dependent kinase-like 2 CDKN2A Cyclin-dependent kinase inhibitor 2A CLOCK Clock circadian regulator CR Calorie restriction CRY1 Cryptochrome circadian regulator 1 CYP450 Cytochrome P450 DAX1 Nuclear receptor subfamily 0 group B member 1 DEN Diethylnitrosamine DHEA Dehydroepiandrosterone DHEA-S DHEA-sulfate DHT Dihydrotestosterone DME Drug metabolizing enzymes E2 Estradiol ER Estrogen receptor EREs Estrogen responsive elements ESR1 Estrogen receptor 1 F Stage of fibrosis FGL1 Fibrinogen like 1 FIB-4 Fibrosis-4 FLI Fatty liver index FMO3 Flavin containing dimethylaniline monoxygenase 3 FOXA1 Forkhead box A1 FOXA2 Forkhead box A2 FSH Follicle-stimulating hormone FXR Farnesoid X receptor GEM Genetically modified models GH Growth hormone GHR Growth hormone receptor GLRA1 Glycine receptor alpha 1 GNMT Glycine N-methyltransferase GnRH Gonadotropin-releasing hormone GPER G Protein-coupled estrogen receptor HBV Hepatitis B virus HCC Hepatocellular carcinoma HCV Hepatitis C virus HFD High-fat-diet HIF1 Hypoxia inducible factor 1 HPG Hypothalamic-pituitary-gonadal axis IL-1 Interleukin 1 Beta JAK Janus kinase KCNIP4 Potassium voltage-gated channel interacting protein 4 KLHL8 Kelch-like family member 8 LDLR Low density lipoprotein receptor LEP Leptin LH Luteinizing hormone LINE1 Long interspersed nuclear element-1 LIPC Lipase C LXR Liver X receptor MASH Metabolic dysfunction-associated steatohepatitis MASLD Metabolic dysfunction-associated steatotic liver disease MASL Metabolic dysfunction-associated steatotic liver MDR2 Multidrug resistance P-glycoprotein 2 MUP-uPA Mice expressing transiently high amounts of urokinase plasminogen activator in hepatocytes NAFLD Non-alcoholic fatty liver disease NFS NAFLD fibrosis score NOTCH2 Notch receptor 2 OVX Ovariectomized PCOS Polycystic ovary syndrome PCSK9 Proprotein convertase subtilisin kexin type 9 PEPCK Phosphoenolpyruvate carboxykinase PER2 Period circadian regulator 2 PPAR Peroxisome proliferator activated receptor alpha PNPLA3 Patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase PPARGC1A PPARG coactivator 1 alpha PPM1L Protein phosphatase, Mg 2+ /Mn 2+ dependent 1L PRKCH Protein kinase C eta PSORS1C1 Psoriasis susceptibility 1 candidate 1 PTEN Phosphatase and tensin homolog PXR Pregnane X receptor REV-ERB Nuclear receptor subfamily 1 group D member 1 RNA-seq RNA-sequencing ROR RAR-related orphan receptor gamma ROS Reactive oxygen species SCN Suprachiasmatic nucleus SNP Single nucleotide polymorphisms SOCS3 Suppressor of cytokine signaling 3 SRC-2 Steroid receptor coactivator-2 SRY Sex-determining region Y STAT Signal transducer and activator of transcription SULT Sulfotransferase TCDD 2,3,7,8-Tetrachlorodibenzo-p-dioxin TCGA The cancer genome atlas TNF Tumor necrosis factor alpha UGT Glucuronosyltransferase Author contributions Conceptualization: KBC and DR