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Several mechanisms may contribute to feelings of fatigue , including: Reduced caloric intake due to appetite suppression Gastrointestinal side effects affecting food and fluid intake Changes in blood glucose regulation Adjustment period as the body adapts to metabolic changes Dehydration from nausea or reduced fluid intake It is important to distinguish between normal tiredness during weight loss and fatigue that may indicate an underlying medical concern

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When at rest, muscles can burn four calories each hour

Diagnosis involves serum B12 measurement (levels below 148 pmol/L indicate deficiency