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125,126,127 The antiviral drug ganciclovir has been shown to improve the intestinal inflammatory response and intestinal mucosal injury in UC mice by inhibiting STING activity in macrophages

They also found that the reduction of histone crotonylation modification can promote the production of dsRNA and dsDNA in the cytoplasm, thereby activating the cGAS-STING pathway and enhancing type I interferon signal transmission, resulting in a tumor suppressor effect (Fig