pancreatic cancer glutathione enhancement Novel drug therapy kills cells by reducing levels of antioxidants Mitophagy in pancreatic cancer: mechanistic

GPX4 catalyzes the reduction of lipid peroxides through selenocysteine (Sec) in its active center, as follows: LOOH+2GSHGPX4LOH+GSSG+H2O LOOH+2GSHGPX4LOH+GSSG+H2O The selenol group (-SeH) of selenocysteine is directly involved in electron transfer and is 100 times more catalytically efficient than regular cysteine (170)

These processes are fundamental in biological systems, setting off a chain of reactions in organisms that utilize oxygen from the air for oxidation, producing energy in the form of ATP (Gulcin 2012

Cell lines were procured form ATCC and included HCT116 (CCL-247), Ca Ski (CRL-1550), SJSA-1 (CRL-2098), A549(CCL-185), Hep G2 (HB-8065), MCF-7 (HTB-22), LoVo (CCL-229), SW48 (CCL-231), SW480(CCL-228), AsPC-1(CRL-1682), HL-60 (CCL-240), LS123 (CCL-255), MDA-MB-361 (HTB-27), MIA PaCa-2 (CRL-1420), HeLa (CCL-2), MS571 (HTB-34), SiHa (HTB-35), NCI-H1299 (CRL-5803), and Saos-2 (HTB-85)

[DOI] [PubMed] [Google Scholar] Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH