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To generate the transgenic lines, we used the skeletal muscle-specific myosin light chain 2 ( mlc2 ) promoter to express the wild-type (WT) human LMNA as well as the five different LMNA mutations, while the heart-specific myosin light chain 7 ( myl7 ) promoter was used to drive the expression of the EGFP transgene as a reporter

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doi:10.1016/j.nmd.2012.11.001