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This keeps the two actives in separate applications entirely and is often the best-tolerated structure

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To locate the IPL voxel we: (a) located the voxel four slices above the last axial view of the ventricles and the first view after the ventricles in the coronal plane, (b) placed one side parallel to the occipito-parietal sulcus, (c) moved the voxel toward the axial midline of the left hemisphere and (d) in the sagittal plane, located it parallel to the inferior parietal sulcus and inspected that this was mostly covered

Trials typically incorporate biomarker endpoints such as ER/ER ratios, aromatase activity, plasma isoflavone or polyphenol concentrations, immune cell phenotyping, cytokine panels, oxidative stress markers and microbiome profile which are used to provide mechanistic read-outs of supplement activity and to inform patient stratification approaches (231)