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Depending on the formulated systems, the release of drugs under different stimuli was achieved, with efficiencies ranging from 23 to 95%

Further mechanistic insights reveal that glucose-starved cells with high expression of SLC7A11 leads to abnormal disulfide bonding within actin cytoskeleton proteins (ACPs), which results in the breakdown of the actin network, detachment of the plasma membrane, and ultimately disulfidptosis cell death (Liu D

It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile

PSEN1, presenilin 1