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81 During S-phase, oxidative DNA damage, including 8-oxoG lesions and strand breaks, activates the MRN-ATM-Chk2 cascade, halting replication to allow repair via p53/p21 activation

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This protein (10 kDa) has a substitution of cys-gly-asp for ser-33 and a carboxyterminal extension of 21 residues

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