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According to a clinical study entitled Physicians Health Study II conducted between 1997 and 2007, which included over 14,000 men over 50, the risk of major cardiovascular events was not reduced by supplementation with vitamins E or C (Lin et al., 2009)

As an isoquinoline alkaloid, berberine is the main effective component of this class, as a multi-target, multi-path plant constituent that interferes with the development of PCOS and related comorbidities with a few adverse reactions (122)

When redox homeostasis is disturbed, oxidative stress contributes to disease development and can also lead to aberrant cell death

Lipid peroxidation at the membrane can disrupt the ion balance and increase membrane permeabilization [12]