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Hassanein et al., 2023)

It is well accepted that melatonin in tablet or capsule form is generally not very bioavailable (1 to 74%) and can be influenced by multiple variables [295]

During these treatments, nutrients are delivered intravenously to bypass the digestive system

Additionally, the efficacy of epigenetic drugs has been limited primarily to hematological malignancies, proving largely ineffective in solid tumors, possibly due to metabolic and epigenetic heterogeneity within tumors