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Release 343 , 645656 (2022)

Although the majority of urinary TMA derives from the reduction of trimethylamine N -oxide (TMAO) (Fig

The excess iron is transported to the extracellular space through the iron transporter protein, or stored in ferritin and reacted with intracellular H 2 O 2 to generate highly active hydroxyl radicals (OH) under slightly acidic conditions, which is known as the Fenton reaction (Fe 2+ + H 2 O 2 Fe 3+ + OH +OH)