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The first was conducted by researchers from the John Hopkins Bloomberg Public School of Health, and the other was run by researchers at the University of Barcelona

The results of a functional analysis suggested reduced activity of mitochondrial Mn-dependent superoxide dismutase (MnSOD2) and impaired respiratory chain function 215

Furthermore, the synovial membrane harbours a substantial population of macrophages that exhibit a proinflammatory phenotype and secrete a plethora of inflammatory mediators [62]