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It is worth noting that gsp-positive tumors are characterized by an increased responsivity to treatment with SS analogs, a feature up to now unexplained since no increase of SS receptors have been found in these tumors (40, 5557)

In line with the observed transcriptional changes of writers and erasers of DNA methylation, 71% of the DMRs corresponded to gain of methylation (46,984 hypermethylated regions vs 19,194 hypomethylated regions)