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Folding the mitochondrial UPR into the integrated stress response

Clin Sao Paulo Braz 79 , 100497

Joint stiffness, connective tissue fatigue, and slower healing from even minor injuries can become part of daily life

The clonal evolution model suggests that cumulative genetic and epigenetic alterations drive tumor progression, whereas the cancer stem cell model posits that a subset of tumor-initiating cells sustains growth and therapeutic resistance