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doi: 10.3389/fpsyt.2022.1070456 Received 14 October 2022 Accepted 20 December 2022 Published 10 January 2023 Volume 13 - 2022 Edited by Murat Ilhan Atagn, anakkale Onsekiz Mart University, Trkiye Reviewed by Kebing Yang, Peking University, China

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32,36 Therefore, on the basis of the in vivo self-assembly nanotechnology developed by our group, we designed a PSMA-targeted nano-PROTAC (Psa-AR) with a proximity degradation effect

INTRINSIC AND ADAPTIVE RESISTANCE: THE TUMOR'S MULTI-LAYERED DEFENSE NETWORK Even in scenarios where ATO uptake and some degree of metabolic activation occur, tumor cells often deploy a formidable array of defensive countermeasures that confer intrinsic or adaptive resistance