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Although clinical trials are limited, the evidence suggests that B12 injections at a dose of at least 500 g three times per week for 2 weeks are effective in relieving chronic low back pain

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In a pool of two ZEPBOUND clinical trials for weight reduction (Studies 1 and 2), 0.2% of ZEPBOUND-treated patients had acute pancreatitis confirmed by adjudication (0.14 patients per 100 years of exposure) versus 0.2% of placebo-treated patients (0.15 patients per 100 years of exposure)