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The functional caspase network in mature erythrocytes cannot be considered just a heritage of the erythroid maturation process but a component of the cell fate decision system, which can be involved in the regulation of the immune response by determining a cell death mode (lytic pro-inflammatory necroptosis vs

doi: 10.3389/fmicb.2022.838164 Received 07 January 2022 Accepted 09 June 2022 Published 04 July 2022 Volume 13 - 2022 Edited by Weiqi He, Soochow University, China Reviewed by Li HuaShan, Soochow University, China

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They are a natural byproduct of metabolism or caused by exposure to toxins in the environment such as tobacco smoke, UV light, and alcohol