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Shoshan-Barmatz, V., Zakar, M., Rosenthal, K

This action is rate-limiting in humans leading to elevated blood concentrations of unmetabolized folic acid when consumption from dietary supplements and fortified foods nears or exceeds the U.S

Heterozygotes are often symptomatic because a significant Heinz body burden can develop even when the unstable variant accounts for only a portion of the total hemoglobin

Work from the authors' laboratory is supported by Associazione Italiana per la Ricerca sul Cancro, European Union Framework Programmes, Ministero dell'Universit e della Ricerca, Compagnia di San Paolo and Fondazione CRT