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Expert Rev Neurother (2018) 18:8390

In M population, the decrease in cyclotide production under heavy metal stress may be explained the reallocation of resources towards other tolerance mechanisms (e.g., metal sequestration or callose production), while in NM population, the increase in cyclotide production suggests an inducible defense response to mitigate oxidative stress or cellular damage caused by heavy metals

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In ongoing therapy rather than recovery, using both simultaneously is less common