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Other potential applications are studying the effects of aging, tissue regeneration in a 3D culture, mutagenesis 14,16 , environmental exposures such as ionizing radiation 36 , long-term effects of drugs or metabolic alterations on cellular states and tissue function or analyzing cellcell interactions

Our current data on the abrogation of the BOK-induced effect on fission following transient overexpression of BOK-BH3 in JEG3 cells further underscore the significance of this domain in regulating fission