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LDN is commonly used as part of a comprehensive treatment plan for: Autoimmune conditions such as Hashimoto's thyroiditis, rheumatoid arthritis, lupus, Sjgren's syndrome, and psoriasis Fibromyalgia and chronic widespread pain Chronic fatigue syndrome (ME/CFS) Multiple sclerosis (MS) Long COVID and post-viral symptom syndromes Chronic inflammation and inflammatory pain Brain fog and cognitive fatigue Migraines and chronic headaches Endometriosis and pelvic pain Neuropathic and nerve-related pain conditions Mast cell activation and complex inflammatory disorders LDN is believed to work by modulating immune activity, supporting endorphin production, and helping reduce inflammatory signaling within the body

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[DOI] [PubMed] [Google Scholar] 320.Presterud, R