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Addressing these questions will thus refine our understanding of the IFN-IChac2GSH signaling axis and strengthen its potential as a therapeutic target in inflammation-driven comorbidities

Based on the existing research evidence, future research should focus on clarifying the molecular mechanism by which gut microbial metabolites regulate lung macrophage polarization and developing targeted intervention strategies (such as MSC exosomes or specific miRNA preparations)

doi: 10.3389/fimmu.2025.1519925 Received 30 October 2024 Accepted 09 January 2025 Published 07 February 2025 Volume 16 - 2025 Edited by Christoph Reinhardt, Johannes Gutenberg University Mainz, Germany Reviewed by Minakshi Rana, Hospital for Special Surgery, United States Pradipta Banerjee, University of Pittsburgh, United States Updates Copyright 2025 Yu, Sun, Yan, Zhou, Liu and Fu