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Smokers in the e-cigarette group received a $26 starter kit, while those in the nicotine-replacement group received a three-month supply of the product of their choice, costing about $159

Large-scale manufacturers leverage their extensive distribution networks, substantial production capacities, and advanced R&D infrastructures to maintain market dominance, while smaller entities often focus on niche segments such as organic blends or region-specific formulations

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Persistent mitochondrial damage in airway epithelium of COPD patients is further evidenced by the increased expression of PINK1, a sensor for damaged mitochondria, and PPARGC1, a regulator of mitochondrial biogenesis [20, 46]