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Lancet Respir Med 2021

& Bodell, W

At 10 dpl, we identified by immunofluorescence newly formed OLs (YFP + cells) being either Bcas1, a marker of immature/pre-myelinating OLs 85 , or GST, a marker restricted to myelinating OLs 78

INTRODUCTION Methotrexate (MTX) is a synthetic antimetabolite with many therapeutic indications, mainly anti-inflammatory and immunosuppressant at relatively low doses and antineoplastic at high doses.[ , ] MTX competitively inhibits dihydrofolate reductase, so decreasing tetrahydrofolate level leads to blocks the synthesis of purines, pyrimidines, DNA, ribonucleic acid, thymidylate, and proteins.[ , , ] It is well known that MTX is a hepatotoxic drug, and this leads to limitation of its clinical use