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In joint tissue models, this translates to documented effects on synovial vascularity and inflammatory mediator expression

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The authors reported that the combination was generally tolerated across the tested levels, with adverse events predominantly gastrointestinal and graded mild to moderate, and that the pharmacokinetic profile was consistent with once-weekly administration in the trial design

Fractional third and fourth dose of RTS,S/AS01 malaria candidate vaccine: a phase 2a controlled human malaria parasite infection and immunogenicity study