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This has resulted in its connection with the development of various diseases, encompassing those affecting the brain, blood, immune system, and heart

Significantly, we found that LSC-Exo exhibited a higher inhibitory activity against SARS-CoV-2 pseudovirus than rhACE2 in vivo, which could be attributed to the rapid degradation and clearance of free rhACE2 in physiological environment

Our study suggests that the regulatory mechanism of SLC3A2 on ferroptosis sensitivity is not limited to the regulation of Xc- transporter stability, but also involves the regulation of AKT-NRF2-GPX4 axis