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Notably, both Fbxo22 knockdown alone and BPC157 treatment promoted proliferation and tubule formation to a similar extent in HUVECs

[1] [2] While feeling cold is not listed as a direct adverse effect in the FDA prescribing information, some patients report increased cold sensitivity during treatment

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Almeida RC, Souza DG, Soletti RC, Lpez MG, Rodrigues AL, Gabilan NH (2006) Involvement of PKA, MAPK/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice