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[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency

2.8 In vivo evaluation of MitoQ and DPI: tolerability and limited efficacy in NB mouse models Finally, to evaluate the efficacy of MitoQ and DPI in vivo , both drugs were administered individually and in combination to Th- MYCN transgenic NB mice