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A broad overview of the science behind growth-hormone-derived peptides is available through the National Center for Biotechnology Informations library of peer-reviewed research on peptide fragments and metabolic signaling, which underscores how preliminary much of this work remains

This often occurs in smokers, people with metabolic disease, heavy alcohol drinkers, as a side effect of certain prescription drugs, rheumatoid arthritis and impaired thyroid function

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Grey market peptides are sold online or through non-medical channels as research grade compounds, labeled not for human consumption, and marketed for weight loss or muscle building