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Glutamine transporter slc1a5 regulates ionizing radiation-derived oxidative damage and ferroptosis

The thiomethyl shunt involves the activity of CCBL to cleave cysteine S-conjugates, and subsequent methylation with an active form of methionine to produce thiomethyl metabolites ( 9, 21 ), meaning that APAP-SG and NAC-APAP were probably biotransformed to APAP-cysteine beforehand

Her groundbreaking work discovered that a protein that is critical for cell survival has two distinct mitochondrial localizations with disparate functions, linking its anti-apoptotic role to a previously unrecognized role in mitochondrial respiration and maintenance of the mitochondrial structure

[DOI] [PubMed] [Google Scholar] 127.Le Gal K., Ibrahim M.X., Wiel C., Sayin V.I., Akula M.K., Karlsson C., Dalin M.G., Akyrek L.M., Lindahl P., Nilsson J., et al